Identify a new antibody that can fight a variety of coronaviruses

U.S.A. researchers have identified a new antibody that can fight the current Covid-19 and different types of coronavirus.
According to the official website of the University of North Carolina at Chapel Hill, scientists at Duke University and the University of North Carolina at Chapel Hill in a joint study have identified and tested a new antibody that strongly Reduces coronavirus infection.

The antibody was identified by a team of scientists at the Duke Human Vaccine Institute (DHVI) and tested on animals at the University of North Carolina at Chapel Hill.

“This antibody has the potential to cure the current epidemic,” said Barton Haynes, director of the Duke Human Vaccine Institute and a member of the research team. The antibody could also be available for future pandemics and other types of coronaviruses that are transmitted from animals to humans.

Heinz and colleagues at the Duke Human Vaccine Institute tested the antibody on the blood of a patient with the main type of coronavirus and a patient with the now common Covid-19.

They identified more than 1,700 antibodies that the immune system produces to bind to specific regions on specific viruses to prevent cells from becoming infected with the pathogen. When viruses mutate, many of the binding points change or are removed, and the antibodies lose their effect. Often, there are places on the virus that remain intact despite the mutations. The team focused on antibodies that target these sites because of their potential to affect different strains of the virus.

Scientists at Duke University found 50 antibodies out of 1,700 antibodies that could bind to both types of coronavirus. Further studies have shown that one of these antibodies is very potent and can bind to several animal coronaviruses in addition to the two pathogens that affect humans.

“This antibody binds to a specific part of the coronavirus that has been conserved in multiple mutations and changes,” Heinz said. As a result, it can neutralize a wide range of coronaviruses.

Scientists at the Duke Human Vaccine Institute used the antibody to refer to scientists at the University of North Carolina at Chapel Hill who specialize in animal coronaviruses. Scientists at the University of North Carolina at Chapel Hill, led by Ralph Baric, a professor of epidemiology at the university, tested the antibody on mice to see if the antibody could effectively stop infections or minimize infections. To send.

They found that the antibody did both. When given to mice before they became infected, the antibody was able to protect them against coronavirus and its variants, such as delta and many animal coronaviruses that have the potential to cause pandemic human diseases.

“The findings of this study provide a model for designing global vaccine development strategies that can provide broad-based protection against known and emerging strains of coronavirus,” Barris said.

When the antibody was administered after infection, it reduced the symptoms of severe lung infection compared to animals not treated with the antibody.

“Therapeutic activity of this antibody, even after infection in mice, shows that this antibody can not only be a cure for the current epidemic, but also to prevent the spread of a disease,” said David Martinez, an epidemiologist at the University of North Carolina at Chapel Hill. The epidemic will be used in the future.

The study was published in the journal Science Translational Medicine.

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