Researchers at the University of Glasgow have shown in a new study that the coronavirus delta can escape the immunity of the vaccine by mutating.
Vaccines have been shown to reduce hospitalization rates and mortality from Covid-19, but new research suggests that the emergence of alarming species of coronavirus may reduce the effectiveness of vaccines.
The study, conducted by scientists at the University of Glasgow Virus Research Center, suggests that delta-type coronavirus may be more successful in escaping the protective response of vaccines.
Mutations modify the protein form of coronavirus clusters, prevent antibody detection, and enable the virus to escape vaccine-induced immunity. The extent to which vaccine recipients are immune to delta is still unknown.
To determine the capacity of different types of coronaviruses, including alpha, beta, and delta to escape the protective immune response of vaccines, the researchers analyzed samples collected from healthy individuals who had received the Pfizer or Astra Zeneca vaccine. Analyzed.
156 people received two doses and 50 people received one dose of the vaccine. They exposed the acute coronavirus syndrome 2 (SARS-CoV-2) proteins in a virus model system to samples obtained from vaccinated individuals and observed and measured the antibody response. They found out how antibodies effectively prevent cell infection and neutralize the virus.
The researchers found that the vaccines protected the body against all types of Covid-19, but also noted a reduction in antibody neutralization in both beta and delta. Delta reduced the immune response by 31.4 and 11.5 times in all Pfizer and Astrazenka vaccine recipients, respectively.
Although this study was consistent with recent findings from the Public Health Organization (PHE) that the vaccine was less effective against delta, it was not designed to directly evaluate the effectiveness of the vaccine. He also did not report on the serological examination of people who received the Moderna or Johnson & Johnson vaccine.
Although vaccines continue to be very effective in preventing severe infections and deaths, continuous monitoring of neutralization against new strains has shown that the virus continues to evolve over time, especially in vulnerable groups.
Booster vaccines reduce the risk of new types of coronavirus currently in circulation. Newer vaccine designs may also be needed to prevent newer strains of the virus, researchers say.
The study was published in the journal PLOS Pathogens.